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Uromodulin
Modulator score = 1020
(score < 50 : weak,
score ≥ 50 : solid )
General Information
Protein
Common name
Uromodulin
Alternative name
Tamm-Horsfall urinary glycoprotein
UniProt ID
P07911
Isoform
P07911
Proteomic database
Protein Atlas
P07911
PeptideAtlas
P07911
Gene
Gene name
uromodulin
Gene symbol
UMOD
Genome annotation database
Ensembl
ENSG00000169344
Modulatory effects
Crystallization
Inhibitor
number of references
4
Systematic analysis of modulating activities of native human urinary Tamm-Horsfall protein on calcium oxalate crystallization, growth, aggregation, crystal-cell adhesion and invasion through extracellular matrix. (2022)
Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both. (2007)
Does Tamm-Horsfall mucoprotein inhibit or promote calcium oxalate crystallization in human urine? (1990)
Tamm and Horsfall glycoprotein does not promote spontaneous precipitation and crystal growth of calcium oxalate in vitro. (1982)
Promoter
number of references
7
Oxidized forms of uromodulin promote calcium oxalate crystallization and growth, but not aggregation. (2022)
Role of Tamm-Horsfall protein and uromodulin in calcium oxalate crystallization. (2002)
The role of Tamm-Horsfall mucoprotein in calcium oxalate crystallization. N-acetylcysteine--a new therapy for calcium oxalate urolithiasis. (1994)
Effects of chondroitin sulphate, human serum albumin and Tamm-Horsfall mucoprotein on calcium oxalate crystallization in undiluted human urine. (1991)
Does Tamm-Horsfall mucoprotein inhibit or promote calcium oxalate crystallization in human urine? (1990)
Possible role of Tamm-Horsfall glycoprotein in calcium oxalate crystallisation. (1989)
Tamm-Horsfall mucoproteins promote calcium oxalate crystal formation in urine: quantitative studies. (1982)
Crystal growth
Inhibitor
number of references
6
Systematic analysis of modulating activities of native human urinary Tamm-Horsfall protein on calcium oxalate crystallization, growth, aggregation, crystal-cell adhesion and invasion through extracellular matrix. (2022)
The role of osteopontin on calcium oxalate crystal formation. (2003)
Effect of Tamm-Horsfall protein on calcium oxalate precipitation. (1995)
Possible role of Tamm-Horsfall glycoprotein in calcium oxalate crystallisation. (1989)
Crystal adsorption and growth slowing by nephrocalcin, albumin, and Tamm-Horsfall protein. (1988)
Tamm and Horsfall glycoprotein does not promote spontaneous precipitation and crystal growth of calcium oxalate in vitro. (1982)
Promoter
number of references
1
Oxidized forms of uromodulin promote calcium oxalate crystallization and growth, but not aggregation. (2022)
Crystal aggregation
Inhibitor
number of references
9
Systematic analysis of modulating activities of native human urinary Tamm-Horsfall protein on calcium oxalate crystallization, growth, aggregation, crystal-cell adhesion and invasion through extracellular matrix. (2022)
Regulation by macromolecules of calcium oxalate crystal aggregation in stone formers. (2005)
The role of osteopontin on calcium oxalate crystal formation. (2003)
Role of Tamm-Horsfall protein and uromodulin in calcium oxalate crystallization. (2002)
Citrate determines calcium oxalate crystallization kinetics and crystal morphology-studies in the presence of Tamm-Horsfall protein of a healthy subject and a severely recurrent calcium stone former. (2000)
Inhibitors within the nephron. (1991)
Effects of chondroitin sulphate, human serum albumin and Tamm-Horsfall mucoprotein on calcium oxalate crystallization in undiluted human urine. (1991)
Does Tamm-Horsfall mucoprotein inhibit or promote calcium oxalate crystallization in human urine? (1990)
Inhibition of calcium oxalate monohydrate crystal aggregation by urine proteins. (1989)
Promoter
number of references
4
Tamm-Horsfall protein in recurrent calcium kidney stone formers with positive family history: abnormalities in urinary excretion, molecular structure and function. (2007)
Role of Tamm-Horsfall protein and uromodulin in calcium oxalate crystallization. (2002)
Citrate determines calcium oxalate crystallization kinetics and crystal morphology-studies in the presence of Tamm-Horsfall protein of a healthy subject and a severely recurrent calcium stone former. (2000)
Effect of Tamm-Horsfall protein on calcium oxalate precipitation. (1995)
Crystal-cell adhesion
Inhibitor
number of references
2
Systematic analysis of modulating activities of native human urinary Tamm-Horsfall protein on calcium oxalate crystallization, growth, aggregation, crystal-cell adhesion and invasion through extracellular matrix. (2022)
Regulation of renal epithelial cell endocytosis of calcium oxalate monohydrate crystals. (1993)
Promoter
number of references
1
Urinary macromolecular inhibition of crystal adhesion to renal epithelial cells is impaired in male stone formers. (2005)