Uromodulin
Modulator score = 1020
(score < 50 : weak, score ≥ 50 : solid )

Experimental evidence∑experimental score = 1000

Modulator functions

number of references  20

Crystal crystallization

PMID/DOI Title name Year
PMID:35263610 Systematic analysis of modulating activities of native human urinary Tamm-Horsfall protein on calcium oxalate crystallization, growth, aggregation, crystal-cell adhesion and invasion through extracellular matrix. 2022
PMID:35752338 Oxidized forms of uromodulin promote calcium oxalate crystallization and growth, but not aggregation. 2022
PMID:17898038 Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both. 2007
PMID:12424489 Role of Tamm-Horsfall protein and uromodulin in calcium oxalate crystallization. 2002
PMID:7953256 The role of Tamm-Horsfall mucoprotein in calcium oxalate crystallization. N-acetylcysteine--a new therapy for calcium oxalate urolithiasis. 1994
PMID:1909472 Effects of chondroitin sulphate, human serum albumin and Tamm-Horsfall mucoprotein on calcium oxalate crystallization in undiluted human urine. 1991
PMID:2253402 Does Tamm-Horsfall mucoprotein inhibit or promote calcium oxalate crystallization in human urine? 1990
PMID:2611614 Possible role of Tamm-Horsfall glycoprotein in calcium oxalate crystallisation. 1989
PMID:7086979 Tamm and Horsfall glycoprotein does not promote spontaneous precipitation and crystal growth of calcium oxalate in vitro. 1982
PMID:7057493 Tamm-Horsfall mucoproteins promote calcium oxalate crystal formation in urine: quantitative studies. 1982

Crystal growth

PMID/DOI Title name Year
PMID:35263610 Systematic analysis of modulating activities of native human urinary Tamm-Horsfall protein on calcium oxalate crystallization, growth, aggregation, crystal-cell adhesion and invasion through extracellular matrix. 2022
PMID:35752338 Oxidized forms of uromodulin promote calcium oxalate crystallization and growth, but not aggregation. 2022
PMID:12706004 The role of osteopontin on calcium oxalate crystal formation. 2003
PMID:8608191 Effect of Tamm-Horsfall protein on calcium oxalate precipitation. 1995
PMID:2611614 Possible role of Tamm-Horsfall glycoprotein in calcium oxalate crystallisation. 1989
PMID:3202183 Crystal adsorption and growth slowing by nephrocalcin, albumin, and Tamm-Horsfall protein. 1988
PMID:7086979 Tamm and Horsfall glycoprotein does not promote spontaneous precipitation and crystal growth of calcium oxalate in vitro. 1982

Crystal aggregation

PMID/DOI Title name Year
PMID:35263610 Systematic analysis of modulating activities of native human urinary Tamm-Horsfall protein on calcium oxalate crystallization, growth, aggregation, crystal-cell adhesion and invasion through extracellular matrix. 2022
PMID:17345077 Tamm-Horsfall protein in recurrent calcium kidney stone formers with positive family history: abnormalities in urinary excretion, molecular structure and function. 2007
PMID:15864572 Regulation by macromolecules of calcium oxalate crystal aggregation in stone formers. 2005
PMID:12706004 The role of osteopontin on calcium oxalate crystal formation. 2003
PMID:12424489 Role of Tamm-Horsfall protein and uromodulin in calcium oxalate crystallization. 2002
PMID:10692522 Citrate determines calcium oxalate crystallization kinetics and crystal morphology-studies in the presence of Tamm-Horsfall protein of a healthy subject and a severely recurrent calcium stone former. 2000
PMID:8608191 Effect of Tamm-Horsfall protein on calcium oxalate precipitation. 1995
PMID:2008908 Inhibitors within the nephron. 1991
PMID:1909472 Effects of chondroitin sulphate, human serum albumin and Tamm-Horsfall mucoprotein on calcium oxalate crystallization in undiluted human urine. 1991
PMID:2253402 Does Tamm-Horsfall mucoprotein inhibit or promote calcium oxalate crystallization in human urine? 1990
PMID:2750929 Inhibition of calcium oxalate monohydrate crystal aggregation by urine proteins. 1989

Crystal-cell adhesion

PMID/DOI Title name Year
PMID:35263610 Systematic analysis of modulating activities of native human urinary Tamm-Horsfall protein on calcium oxalate crystallization, growth, aggregation, crystal-cell adhesion and invasion through extracellular matrix. 2022
PMID:16164655 Urinary macromolecular inhibition of crystal adhesion to renal epithelial cells is impaired in male stone formers. 2005
PMID:8498532 Regulation of renal epithelial cell endocytosis of calcium oxalate monohydrate crystals. 1993
Predicted evidence∑predicted score = 20

Calcium-binding
Oxalate-binding