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Prothrombin (PT)
Modulator score = 275
(score < 50 : weak,
score ≥ 50 : solid )
General Information
Protein
Common name
Prothrombin (PT)
Alternative name
Coagulation factor II
UniProt ID
P00734
Isoform
P00734
Proteomic database
Protein Atlas
P00734
PeptideAtlas
P00734
Gene
Gene name
coagulation factor II, thrombin
Gene symbol
F2
Genome annotation database
Ensembl
ENSG00000180210
Modulatory effects
Crystallization
No solid experimental evidence
Crystal growth
Inhibitor
number of references
3
Effects of urinary prothrombin fragment 1 in the formation of calcium oxalate calculus. (2004)
Inhibition of calcium oxalate crystal growth and aggregation by prothrombin and its fragments in vitro: relationship between protein structure and inhibitory activity. (1999)
Prothrombin gene expression in rat kidneys provides an opportunity to examine its role in urinary stone pathogenesis. (1999)
Crystal aggregation
Inhibitor
number of references
3
Effect of prothrombin and its activation fragments on calcium oxalate crystal growth and aggregation in undiluted human urine in vitro: relationship between protein structure and inhibitory activity. (2002)
Inhibition of calcium oxalate crystal growth and aggregation by prothrombin and its fragments in vitro: relationship between protein structure and inhibitory activity. (1999)
Prothrombin gene expression in rat kidneys provides an opportunity to examine its role in urinary stone pathogenesis. (1999)
Crystal-cell adhesion
Inhibitor
number of references
1
Urinary macromolecular inhibition of crystal adhesion to renal epithelial cells is impaired in male stone formers. (2005)