Prothrombin (PT)
Modulator score = 275
(score < 50 : weak, score ≥ 50 : solid )

Experimental evidence∑experimental score = 250

Modulator functions

number of references  5

Crystal growth

PMID/DOI Title name Year
PMID:15592049 Effects of urinary prothrombin fragment 1 in the formation of calcium oxalate calculus. 2004
PMID:10429186 Inhibition of calcium oxalate crystal growth and aggregation by prothrombin and its fragments in vitro: relationship between protein structure and inhibitory activity. 1999
PMID:10541273 Prothrombin gene expression in rat kidneys provides an opportunity to examine its role in urinary stone pathogenesis. 1999

Crystal aggregation

PMID/DOI Title name Year
PMID:11914105 Effect of prothrombin and its activation fragments on calcium oxalate crystal growth and aggregation in undiluted human urine in vitro: relationship between protein structure and inhibitory activity. 2002
PMID:10429186 Inhibition of calcium oxalate crystal growth and aggregation by prothrombin and its fragments in vitro: relationship between protein structure and inhibitory activity. 1999
PMID:10541273 Prothrombin gene expression in rat kidneys provides an opportunity to examine its role in urinary stone pathogenesis. 1999

Crystal-cell adhesion

PMID/DOI Title name Year
PMID:16164655 Urinary macromolecular inhibition of crystal adhesion to renal epithelial cells is impaired in male stone formers. 2005
Predicted evidence∑predicted score = 25

Calcium-binding
Oxalate-binding