Bikunin
Modulator score = 305
(score < 50 : weak, score ≥ 50 : solid )

Experimental evidence∑experimental score = 300

Modulator functions

number of references  6

Crystal crystallization

PMID/DOI Title name Year
PMID:14516400 Identification of Bikunin isolated from human urine inhibits calcium oxalate crystal growth and its localization in the kidneys. 2003
PMID:11136174 Expression of proteins that inhibit calcium oxalate crystallization in vitro in the urine of normal and stone-forming individuals. 2001
PMID:10541269 Role of urinary bikunin in the inhibition of calcium oxalate crystallization. 1999
PMID:10092154 Role of inter-alpha-inhibitor and its related proteins in urolithiasis. Purification of an inter-alpha-inhibitor related protein from the bovine kidney. 1999
PMID:9607205 Identification of structural domains in inter-alpha-trypsin involved in calcium oxalate crystallization. 1998
PMID:7676539 Characterization of uronic-acid-rich inhibitor of calcium oxalate crystallization isolated from rat urine. 1995

Crystal growth

PMID/DOI Title name Year
PMID:9607205 Identification of structural domains in inter-alpha-trypsin involved in calcium oxalate crystallization. 1998

Crystal aggregation

PMID/DOI Title name Year
PMID:10541269 Role of urinary bikunin in the inhibition of calcium oxalate crystallization. 1999
PMID:9607205 Identification of structural domains in inter-alpha-trypsin involved in calcium oxalate crystallization. 1998
Predicted evidence∑predicted score = 5

Oxalate-binding