Nephrocalcin (Osteocalcin)
Modulator score = 420
(score < 50 : weak, score ≥ 50 : solid )

Experimental evidence∑experimental score = 400

Modulator functions

number of references  8

Crystal crystallization

PMID/DOI Title name Year
PMID:1951713 Evidence that nephrocalcin and urine inhibit nucleation of calcium oxalate monohydrate crystals. 1991

Crystal growth

PMID/DOI Title name Year
PMID:8942630 Characterization of Ca(2+)-binding sites in the kidney stone inhibitor glycoprotein nephrocalcin using vanadyl ions: different metal binding properties in strong and weak inhibitor proteins revealed by EPR and ENDOR. 1996
PMID:7972057 Characterization of calcium-binding sites in the kidney stone inhibitor glycoprotein nephrocalcin with vanadyl ions: electron paramagnetic resonance and electron nuclear double resonance spectroscopy. 1994
PMID:8275352 The effect of warfarin on urine calcium oxalate crystal growth inhibition and urinary excretion of calcium and nephrocalcin. 1993
PMID:2008908 Inhibitors within the nephron. 1991
PMID:3202183 Crystal adsorption and growth slowing by nephrocalcin, albumin, and Tamm-Horsfall protein. 1988

Crystal aggregation

PMID/DOI Title name Year
PMID:2008908 Inhibitors within the nephron. 1991
PMID:2750929 Inhibition of calcium oxalate monohydrate crystal aggregation by urine proteins. 1989

Crystal-cell adhesion

PMID/DOI Title name Year
PMID:7733317 Adhesion of calcium oxalate monohydrate crystals to renal epithelial cells is inhibited by specific anions 1995
Predicted evidence∑predicted score = 20

Calcium-binding