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Osteopontin
Modulator score = 955
(score < 50 : weak,
score ≥ 50 : solid )
General Information
Protein
Common name
Osteopontin
Alternative name
Bone sialoprotein 1, Nephropontin, Secreted phosphoprotein 1 (SPP-1), Urinary stone protein, Uropontin
UniProt ID
P10451
Isoform
P10451
Proteomic database
Protein Atlas
P10451
PeptideAtlas
P10451
Gene
Gene name
secreted phosphoprotein 1
Gene symbol
SPP1
Genome annotation database
Ensembl
ENSG00000118785
Modulatory effects
Crystallization
Inhibitor
number of references
4
On the catalysis of calcium oxalate dihydrate formation by osteopontin peptides. (2012)
Phosphorylation of osteopontin is required for inhibition of calcium oxalate crystallization. (2008)
Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both. (2007)
Contribution of human uropontin to inhibition of calcium oxalate crystallization. (1998)
Promoter
number of references
1
On the catalysis of calcium oxalate dihydrate formation by osteopontin peptides. (2012)
Crystal growth
Inhibitor
number of references
11
Reversible inhibition of calcium oxalate monohydrate growth by an osteopontin phosphopeptide. (2013)
The effect of intracrystalline and surface-bound osteopontin on the attachment of calcium oxalate dihydrate crystals to Madin-Darby canine kidney (MDCK) cells in ultrafiltered human urine. (2011)
Kinetics of calcium oxalate crystal growth in the presence of osteopontin isoforms: an analysis by scanning confocal interference microcopy. (2009)
Modulation of calcium oxalate dihydrate growth by selective crystal-face binding of phosphorylated osteopontin and polyaspartate peptide showing occlusion by sectoral (compositional) zoning. (2009)
Phosphorylation of osteopontin peptides mediates adsorption to and incorporation into calcium oxalate crystals. (2008)
Control of calcium oxalate crystal growth by face-specific adsorption of an osteopontin phosphopeptide. (2007)
Molecular modulation of calcium oxalate crystallization by osteopontin and citrate. (2004)
The role of osteopontin on calcium oxalate crystal formation. (2003)
Contribution of human uropontin to inhibition of calcium oxalate crystallization. (1998)
Identification of a macromolecular crystal growth inhibitor in human urine as osteopontin. (1995)
The calcium oxalate crystal growth inhibitor protein produced by mouse kidney cortical cells in culture is osteopontin. (1992)
Crystal aggregation
Inhibitor
number of references
3
Regulation by macromolecules of calcium oxalate crystal aggregation in stone formers. (2005)
The role of osteopontin on calcium oxalate crystal formation. (2003)
Contribution of human uropontin to inhibition of calcium oxalate crystallization. (1998)
Crystal-cell adhesion
Inhibitor
number of references
4
Contribution of human uropontin to inhibition of calcium oxalate crystallization. (1998)
Osteopontin antisense oligonucleotide inhibits adhesion of calcium oxalate crystals in Madin-Darby canine kidney cell. (1998)
Renal cell osteopontin production is stimulated by calcium oxalate monohydrate crystals. (1997)
Adhesion of calcium oxalate monohydrate crystals to renal epithelial cells is inhibited by specific anions (1995)
Promoter
number of references
1
Urinary macromolecular inhibition of crystal adhesion to renal epithelial cells is impaired in male stone formers. (2005)